Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets▿
Identifieur interne : 001256 ( Main/Exploration ); précédent : 001255; suivant : 001257Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets▿
Auteurs : Zhongying Chen ; Celia Santos ; Amy Aspelund ; Laura Gillim-Ross ; Hong Jin ; George Kemble ; Kanta SubbaraoSource :
- Journal of Virology [ 0022-538X ] ; 2008.
Abstract
Avian influenza A virus A/teal/HK/W312/97 (H6N1) possesses seven gene segments that are highly homologous to those of highly pathogenic human influenza H5N1 viruses, suggesting that a W312-like H6N1 virus might have been involved in the generation of the A/HK/97 H5N1 viruses. The continuous circulation and reassortment of influenza H6 subtype viruses in birds highlight the need to develop an H6 vaccine to prevent potential influenza pandemics caused by the H6 viruses. Based on the serum antibody cross-reactivity data obtained from 14 different H6 viruses from Eurasian and North American lineages, A/duck/HK/182/77, A/teal/HK/W312/97, and A/mallard/Alberta/89/85 were selected to produce live attenuated H6 candidate vaccines. Each of the H6 vaccine strains is a 6:2 reassortant
Url:
DOI: 10.1128/JVI.01775-08
PubMed: 18945773
PubMed Central: 2612304
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Avian influenza A virus A/teal/HK/W312/97 (H6N1) possesses seven gene segments that are highly homologous to those of highly pathogenic human influenza H5N1 viruses, suggesting that a W312-like H6N1 virus might have been involved in the generation of the A/HK/97 H5N1 viruses. The continuous circulation and reassortment of influenza H6 subtype viruses in birds highlight the need to develop an H6 vaccine to prevent potential influenza pandemics caused by the H6 viruses. Based on the serum antibody cross-reactivity data obtained from 14 different H6 viruses from Eurasian and North American lineages, A/duck/HK/182/77, A/teal/HK/W312/97, and A/mallard/Alberta/89/85 were selected to produce live attenuated H6 candidate vaccines. Each of the H6 vaccine strains is a 6:2 reassortant <italic>ca</italic>
virus containing HA and NA gene segments from an H6 virus and the six internal gene segments from cold-adapted A/Ann Arbor/6/60 (AA <italic>ca</italic>
), the master donor virus that is used to make live attenuated influenza virus FluMist (intranasal) vaccine. All three H6 vaccine candidates exhibited phenotypic properties of temperature sensitivity (<italic>ts</italic>
), <italic>ca</italic>
, and attenuation (<italic>att</italic>
) conferred by the internal gene segments from AA <italic>ca</italic>
. Intranasal administration of a single dose of the three H6 <italic>ca</italic>
vaccine viruses induced neutralizing antibodies in mice and ferrets and fully protected mice and ferrets from homologous wild-type (wt) virus challenge. Among the three H6 vaccine candidates, the A/teal/HK/W312/97 <italic>ca</italic>
virus provided the broadest cross-protection against challenge with three antigenically distinct H6 wt viruses. These data support the rationale for further evaluating the A/teal/HK/W312/97 <italic>ca</italic>
vaccine in humans.</p>
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<name sortKey="Gillim Ross, Laura" sort="Gillim Ross, Laura" uniqKey="Gillim Ross L" first="Laura" last="Gillim-Ross">Laura Gillim-Ross</name>
<name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
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<name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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